Version 5.4
Mus musculus Protein: Evpl
Summary
InnateDB Protein IDBP-214434.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Evpl
Protein Name envoplakin
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000037850
InnateDB Gene IDBG-214432 (Evpl)
Protein Structure
UniProt Annotation
Function Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.
Subcellular Localization Cell junction, desmosome {ECO:0000250}. Cornified envelope {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalized with DSP at desmosomes and along intermediate filaments. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030057 desmosome
Protein Structure and Domains
PDB ID MGI:107507
InterPro IPR001101 Plectin repeat
IPR018159 Spectrin/alpha-actinin
PFAM PF00681
PRINTS
PIRSF
SMART SM00250
SM00150
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D952
PhosphoSite PhosphoSite-Q9D952
TrEMBL Q8R167
UniProt Splice Variant
Entrez Gene 14027
UniGene Mm.293683
RefSeq NP_079552
MGI ID
MGI Symbol Evpl
OMIM
CCDS CCDS25661
HPRD
IMGT
EMBL AJ309317 AJ319607 AJ319608 AJ319609 AJ319610 AJ319611 AJ319612 AJ319613 AK007353 AL669925 BC025156
GenPept AAH25156 BAE43204 CAC38864 CAM16385

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca