InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxj1

Summary

InnateDB Protein

IDBP-214448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxj1

Protein Name

forkhead box J1

Synonyms

FKHL-13; HFH-4; Hfh4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038351

InnateDB Gene

IDBG-214446 (Foxj1)

Protein Structure

UniProt Annotation

Function

May play an important role in cell fate determination during lung development and in spermatogenesis.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001947	heart looping
GO:0002508	central tolerance induction
GO:0002635	negative regulation of germinal center formation
GO:0002897	positive regulation of central B cell tolerance induction
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006959	humoral immune response
GO:0007420	brain development
GO:0030036	actin cytoskeleton organization
GO:0030324	lung development
GO:0030856	regulation of epithelial cell differentiation
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032862	activation of Rho GTPase activity
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0035089	establishment of apical/basal cell polarity
GO:0035502	metanephric part of ureteric bud development
GO:0042130	negative regulation of T cell proliferation
GO:0042384	cilium assembly
GO:0045409	negative regulation of interleukin-6 biosynthetic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050869	negative regulation of B cell activation
GO:0050900	leukocyte migration
GO:0060271	cilium morphogenesis
GO:0060429	epithelium development
GO:0060972	left/right pattern formation
GO:0072016	glomerular parietal epithelial cell development
GO:1901248	positive regulation of lung ciliated cell differentiation