InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2o

Summary

InnateDB Protein

IDBP-214483.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2o

Protein Name

ubiquitin-conjugating enzyme E2O

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080791

InnateDB Gene

IDBG-214479 (Ube2o)

Protein Structure

UniProt Annotation

Function

E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin- associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly localizes to the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in reticulocytes. {ECO:0000269PubMed:7761435}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006513	protein monoubiquitination
GO:0008150	biological_process
GO:0030513	positive regulation of BMP signaling pathway
GO:0042147	retrograde transport, endosome to Golgi
GO:0070534	protein K63-linked ubiquitination