Version 5.4
Mus musculus Protein: St6galnac1
Summary
InnateDB Protein IDBP-214516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St6galnac1
Protein Name ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms Siat7a;
Species Mus musculus
Ensembl Protein ENSMUSP00000009732
InnateDB Gene IDBG-214514 (St6galnac1)
Protein Structure
UniProt Annotation
Function Transfers CMP-NeuAc with an alpha-2,6-linkage to the GalNAc residues of GalNAc-O-Ser/Thr, Gal-beta-1,3-GalNAc-O-Ser/Thr and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-O-Ser/Thr are substrates. Higher activity towards GalNAc-O-Ser/Thr. {ECO:0000269PubMed:10788794}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Submaxillary gland, mammary gland, spleen and colon.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006486 protein glycosylation
GO:0009312 oligosaccharide biosynthetic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1341826
InterPro IPR001675 Glycosyl transferase, family 29
PFAM PF00777
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZ39
PhosphoSite PhosphoSite-Q9QZ39
TrEMBL Q9ER78
UniProt Splice Variant
Entrez Gene 20445
UniGene Mm.490616
RefSeq NP_035501
MGI ID
MGI Symbol St6galnac1
OMIM
CCDS CCDS36380
HPRD
IMGT
EMBL AJ271036 AL645542 BC141095 BC145373 BC145374 Y10294 Y11274
GenPept AAI41096 AAI45374 AAI45375 CAA71341 CAA72137 CAC10558 CAM25277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca