InnateDB Protein
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IDBP-214530.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Srsf2
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Protein Name
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serine/arginine-rich splicing factor 2
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Synonyms
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D11Wsu175e; MRF-1; Pr264; SC35; Sfrs10; Sfrs2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000090059
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InnateDB Gene
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IDBG-214528 (Srsf2)
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Protein Structure
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Function |
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre- mRNA (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in all the tissues examined; liver, kidney, spleen, heart, lung and brain. {ECO:0000269PubMed:7527040}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 68 interaction(s) predicted by orthology.
Experimentally validated |
Total |
38
[view]
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Protein-Protein |
20
[view]
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Protein-DNA |
17
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
68 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98284
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InterPro |
IPR000504
RNA recognition motif domain
IPR003954
RNA recognition motif domain, eukaryote
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
SM00361
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TIGRFAMs |
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Modification |
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SwissProt |
Q62093
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PhosphoSite |
PhosphoSite-Q62093
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TrEMBL |
Q99MY5
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UniProt Splice Variant |
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Entrez Gene |
20382
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UniGene |
Mm.469331
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RefSeq |
NP_035488
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MGI ID |
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MGI Symbol |
Srsf2
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OMIM |
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CCDS |
CCDS25680
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HPRD |
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IMGT |
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EMBL |
AF077858
AF250132
AF250135
AK086103
AK088042
AK165670
BC005493
U14648
X98511
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GenPept |
AAA64595
AAC71000
AAH05493
AAK28416
AAK28417
BAC39610
BAC40111
BAE38330
CAA67134
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