InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC25A23

Summary

InnateDB Protein

IDBP-21454.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC25A23

Protein Name

solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000301454

InnateDB Gene

IDBG-21450 (SLC25A23)

Protein Structure

UniProt Annotation

Function

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. {ECO:0000269PubMed:15123600}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600, ECO:0000269PubMed:15716113}; Multi-pass membrane protein {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600, ECO:0000269PubMed:15716113}.

Disease Associations

Tissue Specificity

Present in various cell lines (at protein level). Expressed at low levels in most tissues examined, with highest expression in brain, skeletal muscle and pancreas. {ECO:0000269PubMed:15054102, ECO:0000269PubMed:15123600, ECO:0000269PubMed:15716113}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0002082	regulation of oxidative phosphorylation
GO:0043457	regulation of cellular respiration
GO:0051282	regulation of sequestering of calcium ion
GO:0051503	adenine nucleotide transport
GO:0055085	transmembrane transport
GO:0071277	cellular response to calcium ion
GO:0097274	urea homeostasis

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002048 EF-hand domain
IPR002067 Mitochondrial carrier protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain

PFAM

PF00036
PF13202
PF13405
PF00153

PRINTS

PR00926

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt