InnateDB Protein
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IDBP-214544.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mgat5b
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Protein Name
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mannoside acetylglucosaminyltransferase 5, isoenzyme B
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099316
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InnateDB Gene
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IDBG-214540 (Mgat5b)
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Protein Structure
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Function |
Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway (By similarity). {ECO:0000250}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000269PubMed:16413118}; Single-pass type II membrane protein {ECO:0000269PubMed:16413118}.
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Disease Associations |
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Tissue Specificity |
Present in brain (at protein level). Predominantly expressed in cerebrum and cerebellum. {ECO:0000269PubMed:16413118}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0030144
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alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3606200
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InterPro |
IPR015424
Pyridoxal phosphate-dependent transferase
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q765H6
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PhosphoSite |
PhosphoSite-Q765H6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
268510
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UniGene |
Mm.35141
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RefSeq |
NP_766536
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MGI ID |
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MGI Symbol |
Mgat5b
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OMIM |
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CCDS |
CCDS25682
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HPRD |
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IMGT |
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EMBL |
AB116028
AB119127
AK049266
AL627205
AL663089
BC094604
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GenPept |
AAH94604
BAC33645
BAC87707
BAD08454
CAM23089
CAM23854
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