InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Afmid

Summary

InnateDB Protein

IDBP-214592.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Afmid

Protein Name

arylformamidase

Synonyms

9030621K19Rik; Ammd; FKF; formylase; Kf; KFA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073102

InnateDB Gene

IDBG-214590 (Afmid)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255HAMAP-Rule:MF_03014, ECO:0000269PubMed:12007602}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000255HAMAP- Rule:MF_03014, ECO:0000269PubMed:12411446}. Nucleus {ECO:0000255HAMAP-Rule:MF_03014, ECO:0000269PubMed:12411446}. Note=Predominantly cytosolic. Some fraction is nuclear.

Disease Associations

Tissue Specificity

Highly expressed in liver. Expressed in kidney. Weakly or not expressed in other tissues. {ECO:0000269PubMed:12411446}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004061	arylformamidase activity
GO:0008236	serine-type peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006508	proteolysis
GO:0008152	metabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0034354	'de novo' NAD biosynthetic process from tryptophan

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:2448704

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002018 Carboxylesterase, type B
IPR013094 Alpha/beta hydrolase fold-3
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF00135
PF07859

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K4H1

PhosphoSite