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InnateDB Protein
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IDBP-214626.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Usp36
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Protein Name
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ubiquitin specific peptidase 36
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Synonyms
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2700002L06Rik; mKIAA1453;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000090036
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InnateDB Gene
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IDBG-214622 (Usp36)
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Protein Structure
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| Function |
May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus, nucleolus {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
28 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0008234
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cysteine-type peptidase activity
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GO:0036459
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ubiquitinyl hydrolase activity
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| Biological Process |
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GO:0006511
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ubiquitin-dependent protein catabolic process
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| Cellular Component |
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| PDB ID |
MGI:1919594
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| InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
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| PFAM |
PF00443
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
B1AQJ2
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| PhosphoSite |
PhosphoSite-NP_001028700
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| TrEMBL |
Q8BMX4
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| UniProt Splice Variant |
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| Entrez Gene |
72344
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| UniGene |
Mm.232293
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| RefSeq |
NP_001028700
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| MGI ID |
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| MGI Symbol |
Usp36
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| OMIM |
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| CCDS |
CCDS48998
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| HPRD |
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| IMGT |
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| EMBL |
AK012204
AK129363
AL591404
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| GenPept |
BAC25360
BAC98173
CAM23104
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Version 5.4