Version 5.4
Mus musculus Protein: Fscn2
Summary
InnateDB Protein IDBP-214787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fscn2
Protein Name fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000026445
InnateDB Gene IDBG-214785 (Fscn2)
Protein Structure
UniProt Annotation
Function Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links. {ECO:0000269PubMed:20660251}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:20660251}. Cell projection, stereocilium {ECO:0000269PubMed:20660251}. Note=Found mostly in longer hair- cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips.
Disease Associations Note=Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age- related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant.
Tissue Specificity Expressed in the inner ear.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0008083 growth factor activity
GO:0030674 protein binding, bridging
GO:0051015 actin filament binding
Biological Process
GO:0030036 actin cytoskeleton organization
GO:0042462 eye photoreceptor cell development
Cellular Component
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0032420 stereocilium
Protein Structure and Domains
PDB ID MGI:2443337
InterPro IPR002209 Fibroblast growth factor family
IPR008999 Actin cross-linking
IPR022768 Fascin domain
PFAM PF06268
PRINTS PR00263
PIRSF
SMART SM00442
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q32M02
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 238021
UniGene Mm.481403
RefSeq NP_766390
MGI ID
MGI Symbol Fscn2
OMIM
CCDS CCDS25731
HPRD
IMGT
EMBL AK050002 AL669855 BC109356 BC109357 CH466558
GenPept AAI09357 AAI09358 BAC34026 CAM27038 EDL34739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca