Version 5.4
Mus musculus Protein: Nploc4
Summary
InnateDB Protein IDBP-214796.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nploc4
Protein Name nuclear protein localization 4 homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099306
InnateDB Gene IDBG-214794 (Nploc4)
Protein Structure
UniProt Annotation
Function The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0007030 Golgi organization
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0061025 membrane fusion
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
Protein Structure and Domains
PDB ID MGI:2679787
InterPro IPR001876 Zinc finger, RanBP2-type
IPR007716 NPL4, zinc-binding putative
IPR007717 Nuclear pore localisation protein NPL4
IPR016563 Polyubiquitin-tagged protein recognition complex, Npl4 component
IPR024682 Nuclear pore localisation protein Npl4, ubiquitin-like domain
IPR029071 Ubiquitin-related domain
PFAM PF00641
PF05020
PF05021
PF11543
PRINTS
PIRSF PIRSF010052
SMART SM00547
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P60670
PhosphoSite PhosphoSite-P60670
TrEMBL
UniProt Splice Variant
Entrez Gene 217365
UniGene Mm.473366
RefSeq NP_955763
MGI ID 2PJH
MGI Symbol Nploc4
OMIM
CCDS CCDS25732
HPRD
IMGT
EMBL AK129375 AL669855 BC065156
GenPept AAH65156 BAC98185 CAM27040 CAM27041

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca