Version 5.4
Mus musculus Protein: Slc25a10
Summary
InnateDB Protein IDBP-214829.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc25a10
Protein Name solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10
Synonyms Dic;
Species Mus musculus
Ensembl Protein ENSMUSP00000026899
InnateDB Gene IDBG-214827 (Slc25a10)
Protein Structure
UniProt Annotation
Function Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane.
Subcellular Localization Mitochondrion inner membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed at very high levels in white adipocytes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015114 phosphate ion transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015117 thiosulfate transmembrane transporter activity
GO:0015140 malate transmembrane transporter activity
GO:0015141 succinate transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015297 antiporter activity
Biological Process
GO:0006817 phosphate ion transport
GO:0006839 mitochondrial transport
GO:0008272 sulfate transport
GO:0015709 thiosulfate transport
GO:0015743 malate transport
GO:0015744 succinate transport
GO:0035435 phosphate ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071422 succinate transmembrane transport
GO:0071423 malate transmembrane transport
GO:1902358 sulfate transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1353497
InterPro IPR002030 Mitochondrial brown fat uncoupling protein
IPR018108 Mitochondrial substrate/solute carrier
IPR023395 Mitochondrial carrier domain
PFAM PF00153
PRINTS PR00784
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZD8
PhosphoSite PhosphoSite-Q9QZD8
TrEMBL
UniProt Splice Variant
Entrez Gene 27376
UniGene Mm.3991
RefSeq NP_038798
MGI ID
MGI Symbol Slc25a10
OMIM
CCDS CCDS25738
HPRD
IMGT
EMBL AF188712 AK008038 AK050282 AK151645 BC003222
GenPept AAF03412 AAH03222 BAB25425 BAC34165 BAE30575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca