InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gcgr

Summary

InnateDB Protein

IDBP-214832.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gcgr

Protein Name

glucagon receptor

Synonyms

GR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026119

InnateDB Gene

IDBG-214830 (Gcgr)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269PubMed:12552113, ECO:0000269PubMed:19046568}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12552113}; Multi-pass membrane protein {ECO:0000269PubMed:12552113}. Note=Is rapidly internalized after ligand-binding. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in liver, kidney, adrenal, lung and stomach, while lower levels of expression are detected in brown and white adipose tissue, cerebellum, duodenum and heart. {ECO:0000269PubMed:7590348}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004967	glucagon receptor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0006887	exocytosis
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0009755	hormone-mediated signaling pathway
GO:0042593	glucose homeostasis
GO:0042594	response to starvation
GO:0070873	regulation of glycogen metabolic process
GO:0071377	cellular response to glucagon stimulus

Cellular Component

GO:0005768	endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:99572

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001749 GPCR, family 2, gastric inhibitory polypeptide receptor
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
IPR003291 GPCR, family 2, glucagon receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01129
PR01353
PR01354

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt