InnateDB Protein
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IDBP-214852.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Anapc11
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Protein Name
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anaphase promoting complex subunit 11
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Synonyms
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1110011I19Rik; R75218;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000097714
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InnateDB Gene
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IDBG-214848 (Anapc11)
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Protein Structure
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Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
28 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913406
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InterPro |
IPR001841
Zinc finger, RING-type
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PFAM |
PF13639
PF14634
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PRINTS |
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PIRSF |
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SMART |
SM00184
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CPX9
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PhosphoSite |
PhosphoSite-Q9CPX9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66156
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UniGene |
Mm.21645
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RefSeq |
NP_001033319
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MGI ID |
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MGI Symbol |
Anapc11
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OMIM |
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CCDS |
CCDS25745
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HPRD |
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IMGT |
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EMBL |
AK003244
AK003612
AK003684
AK045408
AK136358
BC023039
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GenPept |
AAH23039
BAB22663
BAB22890
BAB22937
BAC32348
BAE22944
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