InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stra13

Summary

InnateDB Protein

IDBP-214884.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stra13

Protein Name

stimulated by retinoic acid 13

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026137

InnateDB Gene

IDBG-214882 (Stra13)

Protein Structure

UniProt Annotation

Function

DNA-binding component of the FA core complex involved in DNA damage repair and genome maintenance. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. Component of the APITD1/CENPS complex that is essential for the stable assembly of the outer kinetochore. Plays an important role in mitotic progression and chromosome segregation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to chromatin. Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0006281	DNA repair
GO:0007067	mitotic nuclear division
GO:0031297	replication fork processing
GO:0051382	kinetochore assembly