InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rfng

Summary

InnateDB Protein

IDBP-214901.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rfng

Protein Name

RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026156

InnateDB Gene

IDBG-214899 (Rfng)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in all the examined tissues (12.5 dpc). High expression found in adult brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016757	transferase activity, transferring glycosyl groups
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0007389	pattern specification process
GO:0007399	nervous system development
GO:0008152	metabolic process
GO:0030154	cell differentiation
GO:0032092	positive regulation of protein binding
GO:0045747	positive regulation of Notch signaling pathway