InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tex19

Summary

InnateDB Protein

IDBP-214950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tex19

Protein Name

testis expressed gene 19.1

Synonyms

2410081M02Rik; mTex19.1; Tex19; Tex19a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048592

InnateDB Gene

IDBG-214948 (Tex19)

Protein Structure

UniProt Annotation

Function

Required during spermatogenesis and placenta development, probably by participating to the repression of retrotransposable elements and prevent their mobilization. {ECO:0000269PubMed:18802469, ECO:0000269PubMed:21103378, ECO:0000269PubMed:23364048, ECO:0000269PubMed:23674551}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18802469}. Note=Was initially reported to localize in the nucleus (PubMed:18096721). However, it was later shown to localize in cytoplasm only (PubMed:18802469). Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ- cell-specific organelle required to repress transposon activity during meiosis (PubMed:18802469). {ECO:0000269PubMed:18096721, ECO:0000269PubMed:18802469}.

Disease Associations

Tissue Specificity

Expressed in testis, placenta and ovary. Expressed in pluripotent stem cells. In testis, expression is highest in mitotic spermatogonia, decreases as spermatocytes progress through meiosis, and is present at low levels in round spermatids (at protein level). {ECO:0000269PubMed:18096721, ECO:0000269PubMed:18802469, ECO:0000269PubMed:22447323}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001890	placenta development
GO:0007129	synapsis
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0010529	negative regulation of transposition
GO:0010608	posttranscriptional regulation of gene expression
GO:0019953	sexual reproduction
GO:0030154	cell differentiation
GO:0060720	spongiotrophoblast cell proliferation
GO:0060722	cell proliferation involved in embryonic placenta development