InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tbcd

Summary

InnateDB Protein

IDBP-214992.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tbcd

Protein Name

tubulin-specific chaperone d

Synonyms

2310057L06Rik; A030005L14Rik; mKIAA0988;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099302

InnateDB Gene

IDBG-214990 (Tbcd)

Protein Structure

UniProt Annotation

Function

Tubulin-folding protein; involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Acts as a GTPase- activating protein (GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Cell junction, tight junction {ECO:0000250}. Lateral cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Note=Localized in cell- cell contacts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0005515	protein binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0006457	protein folding
GO:0007023	post-chaperonin tubulin folding pathway
GO:0010812	negative regulation of cell-substrate adhesion
GO:0031115	negative regulation of microtubule polymerization
GO:0034333	adherens junction assembly
GO:0043547	positive regulation of GTPase activity
GO:0070830	tight junction assembly