InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: mt-Co2

Summary

InnateDB Protein

IDBP-215026.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

mt-Co2

Protein Name

mitochondrially encoded cytochrome c oxidase II

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080994

InnateDB Gene

IDBG-215024 (mt-Co2)

Protein Structure

UniProt Annotation

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity
GO:0005507	copper ion binding
GO:0016491	oxidoreductase activity

Biological Process

GO:0022900	electron transport chain
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045277	respiratory chain complex IV
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:102503

InterPro

IPR002429 Cytochrome c oxidase subunit II C-terminal
IPR008972 Cupredoxin
IPR011759 Cytochrome C oxidase subunit II, transmembrane domain
IPR014222 Cytochrome c oxidase, subunit II

PFAM

PF00116
PF02790

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00405

PhosphoSite