InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: mt-Atp8

Summary

InnateDB Protein

IDBP-215029.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

mt-Atp8

Protein Name

mitochondrially encoded ATP synthase 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080995

InnateDB Gene

IDBG-215027 (mt-Atp8)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane; Single-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016491	oxidoreductase activity
GO:0016787	hydrolase activity

Biological Process

GO:0015986	ATP synthesis coupled proton transport
GO:0055114	oxidation-reduction process

Cellular Component

GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
GO:0005739	mitochondrion
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016021	integral component of membrane