InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: mt-Atp6

Summary

InnateDB Protein

IDBP-215032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

mt-Atp6

Protein Name

mitochondrially encoded ATP synthase 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080996

InnateDB Gene

IDBG-215030 (mt-Atp6)

Protein Structure

UniProt Annotation

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

Subcellular Localization

Mitochondrion inner membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015078	hydrogen ion transmembrane transporter activity
GO:0016887	ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0015986	ATP synthesis coupled proton transport

Cellular Component

GO:0005739	mitochondrion
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0016021	integral component of membrane
GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)
GO:0070062	extracellular vesicular exosome