Version 5.4
Mus musculus Protein: mt-Nd4
Summary
InnateDB Protein IDBP-215044.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol mt-Nd4
Protein Name mitochondrially encoded NADH dehydrogenase 4
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081000
InnateDB Gene IDBG-215042 (mt-Nd4)
Protein Structure
UniProt Annotation
Function Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0042773 ATP synthesis coupled electron transport
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005747 mitochondrial respiratory chain complex I
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:102498
InterPro IPR000260 NADH:ubiquinone oxidoreductase, chain 4, N-terminal
IPR001750 NADH:ubiquinone/plastoquinone oxidoreductase
IPR003918 NADH:ubiquinone oxidoreductase
IPR010227 NADH-quinone oxidoreductase, chain M/4
PFAM PF01059
PF00361
PRINTS PR01437
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P03911
PhosphoSite PhosphoSite-
TrEMBL Q7JCY6
UniProt Splice Variant
Entrez Gene 17719
UniGene Mm.458030
RefSeq NP_904337
MGI ID
MGI Symbol mt-Nd4
OMIM
CCDS
HPRD
IMGT
EMBL AB042523 AB049357 AJ489607 AJ512208 AK142750 AP013030 AP013031 AY172335 AY339599 AY466499 AY533105 AY533106 AY533107 AY533108 AY999076 DQ106412 DQ106413 EF108330 EF108331 EF108332 EF108333 EF108334 EF108335 EF108336 EF108337 EF108338 EF108339 EF108340 EF108341 EU315228 EU315229 EU450583 FJ803909 HQ586004 HQ675026 HQ675027 HQ675028 HQ675029 HQ675030 HQ675031 HQ877407 J01420 JQ003190 V00711
GenPept AAB48653 AAN85131 AAP89032 AAR21204 AAS01435 AAS01448 AAS01461 AAS01474 AAX83021 AAY96698 AAY96711 ABK79102 ABK79115 ABK79128 ABK79141 ABK79154 ABK79167 ABK79180 ABK79193 ABK79206 ABK79219 ABK79232 ABK79245 ABX79737 ABX79750 ACA01532 ACN91104 ADR03165 ADW83075 AEN03378 AEN03391 AEN03404 AEN03417 AEN03430 AEN03443 AEV56606 BAA95662 BAB13810 BAE25184 BAM93592 BAM93605 CAA24091 CAD33916 CAD54441

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca