InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL6ST

Summary

InnateDB Protein

IDBP-21518.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL6ST

Protein Name

interleukin 6 signal transducer (gp130, oncostatin M receptor)

Synonyms

CD130; CDW130; GP130; IL-6RB;

Species

Homo sapiens

Ensembl Protein

ENSP00000370698

InnateDB Gene

IDBG-21516 (IL6ST)

Protein Structure

UniProt Annotation

Function

Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	53 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0004915	interleukin-6 receptor activity
GO:0004921	interleukin-11 receptor activity
GO:0004923	leukemia inhibitory factor receptor activity
GO:0004924	oncostatin-M receptor activity
GO:0005127	ciliary neurotrophic factor receptor binding
GO:0005138	interleukin-6 receptor binding
GO:0005515	protein binding
GO:0019838	growth factor binding
GO:0019970	interleukin-11 binding
GO:0019981	interleukin-6 binding
GO:0042803	protein homodimerization activity
GO:0045509	interleukin-27 receptor activity

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0002821	positive regulation of adaptive immune response
GO:0005977	glycogen metabolic process
GO:0007165	signal transduction
GO:0008284	positive regulation of cell proliferation
GO:0008593	regulation of Notch signaling pathway
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010613	positive regulation of cardiac muscle hypertrophy
GO:0016032	viral process
GO:0019221	cytokine-mediated signaling pathway
GO:0034097	response to cytokine
GO:0038154	interleukin-11-mediated signaling pathway
GO:0038165	oncostatin-M-mediated signaling pathway
GO:0042102	positive regulation of T cell proliferation
GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045669	positive regulation of osteoblast differentiation
GO:0048711	positive regulation of astrocyte differentiation
GO:0048861	leukemia inhibitory factor signaling pathway
GO:0070102	interleukin-6-mediated signaling pathway
GO:0070104	negative regulation of interleukin-6-mediated signaling pathway
GO:0070106	interleukin-27-mediated signaling pathway
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005896	interleukin-6 receptor complex
GO:0005900	oncostatin-M receptor complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0044297	cell body
GO:0070062	extracellular vesicular exosome
GO:0070110	ciliary neurotrophic factor receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR003961 Fibronectin, type III
IPR010457 Immunoglobulin C2-set-like, ligand-binding
IPR015152 Growth hormone/erythropoietin receptor, ligand binding
IPR015321 Interleukin-6 receptor alpha, binding

PFAM

PF00041
PF01108
PF06328
PF09067
PF09240

PRINTS

PIRSF

SMART

SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P40189