InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNH8

Summary

InnateDB Protein

IDBP-21595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNH8

Protein Name

potassium voltage-gated channel, subfamily H (eag-related), member 8

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000328813

InnateDB Gene

IDBG-21593 (KCNH8)

Protein Structure

UniProt Annotation

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Primarily expressed in the nervous system. {ECO:0000269PubMed:12890647}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000155	phosphorelay sensor kinase activity
GO:0000166	nucleotide binding
GO:0004871	signal transducer activity
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0023014	signal transduction by phosphorylation
GO:0034765	regulation of ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0055085	transmembrane transport
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR000595 Cyclic nucleotide-binding domain
IPR000700 PAS-associated, C-terminal
IPR001610 PAC motif
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR003949 Potassium channel, voltage-dependent, EAG
IPR003950 Potassium channel, voltage-dependent, ELK
IPR003967 Potassium channel, voltage-dependent, ERG
IPR005821 Ion transport domain
IPR010978 tRNA-binding arm
IPR013099 Two pore domain potassium channel domain
IPR013655 PAS fold-3
IPR013656 PAS fold-4
IPR013767 PAS fold
IPR018490 Cyclic nucleotide-binding-like

PFAM