InnateDB Protein
|
IDBP-21615.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
CKB
|
Protein Name
|
creatine kinase, brain
|
Synonyms
|
B-CK; BCK; CKBB; HEL-211; HEL-S-29;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000299198
|
InnateDB Gene
|
IDBG-21613 (CKB)
|
Protein Structure
|
|
Function |
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
|
Subcellular Localization |
Cytoplasm.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
59
[view]
|
Protein-Protein |
59
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR022413
ATP:guanido phosphotransferase, N-terminal
IPR022414
ATP:guanido phosphotransferase, catalytic domain
|
PFAM |
PF02807
PF00217
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P12277
|
PhosphoSite |
PhosphoSite-P12277
|
TrEMBL |
V9HWH2
|
UniProt Splice Variant |
|
Entrez Gene |
1152
|
UniGene |
|
RefSeq |
NP_001814
|
HUGO |
HGNC:1991
|
OMIM |
123280
|
CCDS |
CCDS9981
|
HPRD |
00423
|
IMGT |
|
EMBL |
AK290101
AK312282
AL133367
BC001190
BC004914
BC008323
BC010002
BC019259
BC019281
CH471061
CR542268
DQ333313
EU794629
L47647
M16364
M16451
M21237
M21238
M21239
M21240
M21241
M21242
M21243
M22355
M22356
X15334
|
GenPept |
AAA52024
AAA76850
AAA76851
AAA76852
AAC31758
AAH01190
AAH04914
AAH08323
AAH10002
AAH19259
AAH19281
ABC67465
ACJ13683
BAF82790
BAG35211
CAA33389
CAG47064
EAW81822
|
|
|