InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSPH1

Summary

InnateDB Protein

IDBP-21618.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSPH1

Protein Name

heat shock 105kDa/110kDa protein 1

Synonyms

HSP105; HSP105A; HSP105B; NY-CO-25;

Species

Homo sapiens

Ensembl Protein

ENSP00000318687

InnateDB Gene

IDBG-21616 (HSPH1)

Protein Structure

UniProt Annotation

Function

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9931472}.

Disease Associations

Tissue Specificity

Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. {ECO:0000269PubMed:10865058, ECO:0000269PubMed:16232202}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	65 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0043014	alpha-tubulin binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006986	response to unfolded protein
GO:0045345	positive regulation of MHC class I biosynthetic process
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051135	positive regulation of NK T cell activation

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen

Protein Structure and Domains

PDB ID

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92598