InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DERL2

Summary

InnateDB Protein

IDBP-21632.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DERL2

Protein Name

Der1-like domain family, member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000158771

InnateDB Gene

IDBG-21628 (DERL2)

Protein Structure

UniProt Annotation

Function

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. {ECO:0000269PubMed:15215855, ECO:0000269PubMed:16186509, ECO:0000269PubMed:16449189}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15215855, ECO:0000269PubMed:16449189}; Multi- pass membrane protein {ECO:0000269PubMed:15215855, ECO:0000269PubMed:16449189}.

Disease Associations

Tissue Specificity

Ubiquitous. Overexpressed in various hepatocarcinomas. {ECO:0000269PubMed:11500051, ECO:0000269PubMed:16449189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001967	suckling behavior
GO:0008284	positive regulation of cell proliferation
GO:0030307	positive regulation of cell growth
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0030970	retrograde protein transport, ER to cytosol

Cellular Component

GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0030176	integral component of endoplasmic reticulum membrane