Version 5.4
Homo sapiens Protein: HS3ST4
Summary
InnateDB Protein IDBP-21638.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HS3ST4
Protein Name heparan sulfate (glucosamine) 3-O-sulfotransferase 4
Synonyms 3-OST-4; 30ST4; 3OST4; h3-OST-4;
Species Homo sapiens
Ensembl Protein ENSP00000330606
InnateDB Gene IDBG-21636 (HS3ST4)
Protein Structure
UniProt Annotation
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Brain-specific. {ECO:0000269PubMed:9988767}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008146 sulfotransferase activity
GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
Biological Process
GO:0030201 heparan sulfate proteoglycan metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000863 Sulfotransferase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00685
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y661
PhosphoSite PhosphoSite-
TrEMBL A5H458
UniProt Splice Variant
Entrez Gene 9951
UniGene Hs.655275
RefSeq NP_006031
HUGO HGNC:5200
OMIM 604059
CCDS CCDS53995
HPRD 04960
IMGT
EMBL AC092141 AC093511 AF105378 AL834283 AY476736 EF063601 EF063602 EF063603 EF063604 EF063605 EF063606 EF063607 EF063608
GenPept AAD30210 AAS58324 ABN79912 ABN79913 ABN79914 ABN79915 ABN79916 ABN79917 ABN79918 ABN79919 CAD38957

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca