InnateDB Protein
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IDBP-21674.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ATP6V1H
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Protein Name
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ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000347359
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InnateDB Gene
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IDBG-21670 (ATP6V1H)
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Protein Structure
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Function |
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. {ECO:0000250}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:9620685}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005488
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binding
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GO:0005515
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protein binding
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GO:0016820
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hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
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GO:0016887
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ATPase activity
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GO:0030234
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enzyme regulator activity
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GO:0046961
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proton-transporting ATPase activity, rotational mechanism
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004908
ATPase, V1 complex, subunit H
IPR011987
ATPase, V1 complex, subunit H, C-terminal
IPR016024
Armadillo-type fold
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PFAM |
PF03224
PF11698
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PRINTS |
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PIRSF |
PIRSF032184
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UI12
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PhosphoSite |
PhosphoSite-Q9UI12
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TrEMBL |
E5RHH0
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UniProt Splice Variant |
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Entrez Gene |
51606
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UniGene |
Hs.491737
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RefSeq |
NP_998784
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HUGO |
HGNC:18303
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OMIM |
608861
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CCDS |
CCDS6154
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HPRD |
10591
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IMGT |
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EMBL |
AC022887
AC103778
AC113194
AF112204
AF113222
AF132945
AF298777
AK022345
BC025275
CH471068
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GenPept |
AAD27720
AAF17192
AAG22809
AAG39293
AAH25275
BAG51072
EAW86727
EAW86728
EAW86729
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