InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFSF9

Summary

InnateDB Protein

IDBP-21690.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFSF9

Protein Name

tumor necrosis factor (ligand) superfamily, member 9

Synonyms

4-1BB-L; CD137L;

Species

Homo sapiens

Ensembl Protein

ENSP00000245817

InnateDB Gene

IDBG-21688 (TNFSF9)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269PubMed:20032458}.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Expressed in brain, placenta, lung, skeletal muscle and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding
GO:0032813	tumor necrosis factor receptor superfamily binding

Biological Process

GO:0006915	apoptotic process
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0032729	positive regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0042104	positive regulation of activated T cell proliferation
GO:0042127	regulation of cell proliferation
GO:0043011	myeloid dendritic cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045585	positive regulation of cytotoxic T cell differentiation