InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD70

Summary

InnateDB Protein

IDBP-21701.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD70

Protein Name

CD70 molecule

Synonyms

CD27L; CD27LG; TNFSF7;

Species

Homo sapiens

Ensembl Protein

ENSP00000245903

InnateDB Gene

IDBG-21699 (CD70)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005102	receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008283	cell proliferation
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome