InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAB5A

Summary

InnateDB Protein

IDBP-21704.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB5A

Protein Name

RAB5A, member RAS oncogene family

Synonyms

RAB5;

Species

Homo sapiens

Ensembl Protein

ENSP00000273047

InnateDB Gene

IDBG-21702 (RAB5A)

Protein Structure

UniProt Annotation

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. {ECO:0000269PubMed:10818110, ECO:0000269PubMed:14617813, ECO:0000269PubMed:14978216, ECO:0000269PubMed:15378032, ECO:0000269PubMed:16410077}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Melanosome. Cytoplasmic vesicle {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Membrane. Cytoplasm, cytosol. Note=Enriched in stage I melanosomes. Alternates between membrane-bound and cytosolic forms.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	86 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0019003	GDP binding
GO:0051021	GDP-dissociation inhibitor binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0007596	blood coagulation
GO:0014911	positive regulation of smooth muscle cell migration
GO:0015031	protein transport
GO:0030154	cell differentiation
GO:0045921	positive regulation of exocytosis
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051489	regulation of filopodium assembly
GO:2000286	receptor internalization involved in canonical Wnt receptor signaling pathway

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0010008	endosome membrane
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030139	endocytic vesicle
GO:0030424	axon
GO:0030425	dendrite
GO:0031901	early endosome membrane
GO:0042470	melanosome
GO:0042589	zymogen granule membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0045335	phagocytic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF04670
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt