InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NSMCE1

Summary

InnateDB Protein

IDBP-21743.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSMCE1

Protein Name

non-SMC element 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000355077

InnateDB Gene

IDBG-21741 (NSMCE1)

Protein Structure

UniProt Annotation

Function

Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus. {ECO:0000269PubMed:18086888, ECO:0000269PubMed:20864041}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18086888}. Chromosome, telomere {ECO:0000305PubMed:18086888}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:2001022	positive regulation of response to DNA damage stimulus

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0030915	Smc5-Smc6 complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001841 Zinc finger, RING-type
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR011513 Non-structural maintenance of chromosomes element 1
IPR014857 Zinc finger, RING-like

PFAM

PF13639
PF14634
PF00130
PF07574
PF08746

PRINTS

PIRSF

SMART

SM00184
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WV22