InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS20

Summary

InnateDB Protein

IDBP-21788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS20

Protein Name

regulator of G-protein signaling 20

Synonyms

g(z)GAP; gz-GAP; RGSZ1; ZGAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000297313

InnateDB Gene

IDBG-21786 (RGS20)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity