InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LYPLA1

Summary

InnateDB Protein

IDBP-21887.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LYPLA1

Protein Name

lysophospholipase I

Synonyms

APT-1; APT1; hAPT1; LPL-I; LPL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000320043

InnateDB Gene

IDBG-21885 (LYPLA1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity. {ECO:0000269PubMed:20418879, ECO:0000269PubMed:22399288}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004622	lysophospholipase activity
GO:0008474	palmitoyl-(protein) hydrolase activity
GO:0016787	hydrolase activity

Biological Process

GO:0002084	protein depalmitoylation
GO:0006631	fatty acid metabolic process
GO:0008152	metabolic process
GO:0042997	negative regulation of Golgi to plasma membrane protein transport
GO:0044281	small molecule metabolic process
GO:0046209	nitric oxide metabolic process
GO:0050999	regulation of nitric-oxide synthase activity