InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SULT1E1

Summary

InnateDB Protein

IDBP-21957.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SULT1E1

Protein Name

sulfotransferase family 1E, estrogen-preferring, member 1

Synonyms

EST; EST-1; ST1E1; STE;

Species

Homo sapiens

Ensembl Protein

ENSP00000226444

InnateDB Gene

IDBG-21955 (SULT1E1)

Protein Structure

UniProt Annotation

Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated. {ECO:0000269PubMed:11884392}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Liver, intestine and at lower level in the kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004304	estrone sulfotransferase activity
GO:0005496	steroid binding
GO:0008146	sulfotransferase activity
GO:0047894	flavonol 3-sulfotransferase activity
GO:0050294	steroid sulfotransferase activity

Biological Process

GO:0006805	xenobiotic metabolic process
GO:0007565	female pregnancy
GO:0008202	steroid metabolic process
GO:0008210	estrogen metabolic process
GO:0044281	small molecule metabolic process
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0051923	sulfation