InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RXFP2

Summary

InnateDB Protein

IDBP-22015.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RXFP2

Protein Name

relaxin/insulin-like family peptide receptor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000298386

InnateDB Gene

IDBG-22013 (RXFP2)

Protein Structure

UniProt Annotation

Function

Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Cryptorchidism (CRYPTO) [MIM:219050]: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. {ECO:0000269PubMed:12217959}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0016500	protein-hormone receptor activity
GO:0017046	peptide hormone binding

Biological Process

GO:0001556	oocyte maturation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001611 Leucine-rich repeat
IPR002131 Glycoprotein hormone receptor family
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR008112 Relaxin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001
PF00560
PF13504
PF13855
PF00057

PRINTS

PR00237
PR00373
PR00261
PR01739

PIRSF

SMART

SM00192
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt