Homo sapiens Protein: SH2D3A
Summary
InnateDB Protein IDBP-22028.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH2D3A
Protein Name SH2 domain containing 3A
Synonyms NSP1;
Species Homo sapiens
Ensembl Protein ENSP00000245908
InnateDB Gene IDBG-22026 (SH2D3A)
Protein Structure
UniProt Annotation
Function May play a role in JNK activation.
Subcellular Localization
Disease Associations
Tissue Specificity Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung. {ECO:0000269PubMed:10187783}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007254 JNK cascade
GO:0007264 small GTPase mediated signal transduction
GO:0009967 positive regulation of signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR023578 Ras guanine nucleotide exchange factor domain
PFAM PF00017
PF14633
PF00617
PRINTS PR00401
PIRSF
SMART SM00252
SM00147
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRG2
PhosphoSite PhosphoSite-Q9BRG2
TrEMBL
UniProt Splice Variant
Entrez Gene 10045
UniGene Hs.619761
RefSeq NP_005481
HUGO HGNC:16885
OMIM 604721
CCDS CCDS12173
HPRD 05283
IMGT
EMBL AF124249 AK292781 AY358406 BC006281 CH471139
GenPept AAD28244 AAH06281 AAQ88772 BAF85470 EAW69059