InnateDB Protein
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IDBP-22031.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE2E1
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Protein Name
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ubiquitin-conjugating enzyme E2E 1
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Synonyms
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UBCH6;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303709
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InnateDB Gene
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IDBG-22029 (UBE2E1)
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Protein Structure
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Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. {ECO:0000269PubMed:16428300, ECO:0000269PubMed:20061386}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:18845142}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 119 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
119
[view]
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Protein-Protein |
119
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0000209
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protein polyubiquitination
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GO:0000278
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mitotic cell cycle
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0007094
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mitotic spindle assembly checkpoint
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GO:0010390
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histone monoubiquitination
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GO:0016567
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protein ubiquitination
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0032020
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ISG15-protein conjugation
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GO:0033523
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histone H2B ubiquitination
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GO:0051436
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negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051437
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positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0051439
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regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
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GO:0070936
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protein K48-linked ubiquitination
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Cellular Component |
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PDB ID |
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P51965
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PhosphoSite |
PhosphoSite-P51965
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TrEMBL |
C9J2P0
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UniProt Splice Variant |
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Entrez Gene |
7324
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UniGene |
Hs.732678
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RefSeq |
NP_003332
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HUGO |
HGNC:12477
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OMIM |
602916
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CCDS |
CCDS2638
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HPRD |
04225
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IMGT |
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EMBL |
AC020626
AC124914
AK314854
BC009139
BI223271
BI666638
CH471055
X92963
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GenPept |
AAH09139
BAG37371
CAA63539
EAW64329
EAW64331
EAW64332
EAW64333
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