InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAV1

Summary

InnateDB Protein

IDBP-22057.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAV1

Protein Name

vav 1 guanine nucleotide exchange factor

Synonyms

VAV;

Species

Homo sapiens

Ensembl Protein

ENSP00000302269

InnateDB Gene

IDBG-22055 (VAV1)

Protein Structure

UniProt Annotation

Function

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed in hematopoietic cells but not in other cell types.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 130 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	130 [view]
Protein-Protein	127 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR003096 Smooth muscle protein/calponin
IPR011511 Variant SH3 domain
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM