InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MEP1B

Summary

InnateDB Protein

IDBP-2211.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MEP1B

Protein Name

meprin A, beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000269202

InnateDB Gene

IDBG-2209 (MEP1B)

Protein Structure

UniProt Annotation

Function

Membrane metallopeptidase that sheds many membrane-bound proteins. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components. {ECO:0000269PubMed:21693781}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Secreted. Note=Homodimers are essentially membrane bound but may also be shed from the surface by ADAM-10 and ADAM-17.

Disease Associations

Tissue Specificity

The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells. {ECO:0000269PubMed:12387727}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0006954	inflammatory response
GO:0007586	digestion

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000998 MAM domain
IPR001506 Peptidase M12A, astacin
IPR002083 MATH
IPR006026 Peptidase, metallopeptidase
IPR008294 Meprin alpha/beta subunit
IPR008974 TRAF-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00008
PF00629
PF01400
PF00917

PRINTS

PR00020
PR00480

PIRSF

PIRSF001196

SMART

SM00181
SM00137
SM00061
SM00235

TIGRFAMs

Post-translational Modifications

Modification

Cross-References