Version 5.4
Homo sapiens Protein: ZFYVE21
Summary
InnateDB Protein IDBP-22118.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE21
Protein Name zinc finger, FYVE domain containing 21
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000216602
InnateDB Gene IDBG-22114 (ZFYVE21)
Protein Structure
UniProt Annotation
Function Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta-1/ITGB1 cell surface expression. {ECO:0000269PubMed:20439989, ECO:0000269PubMed:21768110}.
Subcellular Localization Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
Cellular Component
GO:0005768 endosome
GO:0005925 focal adhesion
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID
InterPro IPR000306 FYVE zinc finger
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related
PFAM PF01363
PRINTS
PIRSF
SMART SM00064
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQ24
PhosphoSite PhosphoSite-Q9BQ24
TrEMBL
UniProt Splice Variant
Entrez Gene 79038
UniGene Hs.705283
RefSeq NP_001185882
HUGO HGNC:20760
OMIM 613504
CCDS CCDS55948
HPRD 15733
IMGT
EMBL AK057816 AK290519 AY395756 BC001130 BC005999 BX248261 CH471061
GenPept AAH01130 AAH05999 AAR14313 BAB71589 BAF83208 CAD62589 EAW81844

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca