Version 5.4
Homo sapiens Protein: STATH
Summary
InnateDB Protein IDBP-22139.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STATH
Protein Name statherin
Synonyms STR;
Species Homo sapiens
Ensembl Protein ENSP00000246895
InnateDB Gene IDBG-22137 (STATH)
Protein Structure
UniProt Annotation
Function Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation on the tooth surface.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Secreted by parotid and submandibular glands.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030197 extracellular matrix constituent, lubricant activity
GO:0030345 structural constituent of tooth enamel
GO:0046848 hydroxyapatite binding
Biological Process
GO:0001503 ossification
GO:0030502 negative regulation of bone mineralization
GO:0031214 biomineral tissue development
GO:0046541 saliva secretion
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR005575 Statherin
PFAM PF03875
PRINTS
PIRSF PIRSF002565
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P02808
PhosphoSite PhosphoSite-P02808
TrEMBL
UniProt Splice Variant
Entrez Gene 6779
UniGene
RefSeq
HUGO HGNC:11369
OMIM 184470
CCDS CCDS3533
HPRD 01696
IMGT
EMBL AC063956 AK311812 BC067219 CH471057 M18078 M18371 M32639
GenPept AAA60593 AAA60594 AAA60600 AAH67219 BAG34755 EAX05604 EAX05605

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca