InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FRY

Summary

InnateDB Protein

IDBP-22199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FRY

Protein Name

furry homolog (Drosophila)

Synonyms

13CDNA73; 214K23.2; bA207N4.2; bA37E23.1; C13orf14; CG003;

Species

Homo sapiens

Ensembl Protein

ENSP00000369600

InnateDB Gene

IDBG-22193 (FRY)

Protein Structure

UniProt Annotation

Function

Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. {ECO:0000269PubMed:22753416}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22753416}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:22753416}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:22753416}. Note=Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.