Version 5.4
Homo sapiens Protein: HTN1
Summary
InnateDB Protein IDBP-22215.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HTN1
Protein Name histatin 1
Synonyms HIS1;
Species Homo sapiens
Ensembl Protein ENSP00000246896
InnateDB Gene IDBG-22213 (HTN1)
Protein Structure
UniProt Annotation
Function Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Submandibular and parotid glands. {ECO:0000269PubMed:17503797}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031214 biomineral tissue development
GO:0031640 killing of cells of other organism
GO:0042742 defense response to bacterium
GO:0050832 defense response to fungus
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15515
PhosphoSite PhosphoSite-P15515
TrEMBL
UniProt Splice Variant
Entrez Gene 3346
UniGene Hs.599304
RefSeq
HUGO HGNC:5283
OMIM 142701
CCDS CCDS3534
HPRD 00814
IMGT
EMBL BC017835 L04132 M26664
GenPept AAA02745 AAA58645 AAH17835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca