InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GART

Summary

InnateDB Protein

IDBP-2230.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GART

Protein Name

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

Synonyms

AIRS; GARS; GARTF; PAIS; PGFT; PRGS;

Species

Homo sapiens

Ensembl Protein

ENSP00000354388

InnateDB Gene

IDBG-2218 (GART)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004637	phosphoribosylamine-glycine ligase activity
GO:0004641	phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644	phosphoribosylglycinamide formyltransferase activity
GO:0005524	ATP binding
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006189	'de novo' IMP biosynthetic process
GO:0009113	purine nucleobase biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0032259	methylation
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000115 Phosphoribosylglycinamide synthetase
IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR011054 Rudiment single hybrid motif
IPR011761 ATP-grasp fold
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR016185 Pre-ATP-grasp domain
IPR020560 Phosphoribosylglycinamide synthetase, C-domain
IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
IPR020562 Phosphoribosylglycinamide synthetase, N-terminal

PFAM

PF02222
PF02786
PF08442
PF02843
PF01071
PF02844

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P22102

PhosphoSite