Homo sapiens Protein: TDRD9 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-22303.7 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | TDRD9 | ||||||||||||||||||
Protein Name | tudor domain containing 9 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000343545 | ||||||||||||||||||
InnateDB Gene | IDBG-22301 (TDRD9) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Probable ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with PIWIL4 and the piP-bodies suggests a participation in the secondary piRNAs metabolic process (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies (By similarity). {ECO:0000250}. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001650
Helicase, C-terminal IPR002999 Tudor domain IPR007502 Helicase-associated domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00271
PF00567 PF04408 |
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PRINTS | |||||||||||||||||||
PIRSF | |||||||||||||||||||
SMART |
SM00490
SM00333 SM00847 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q8NDG6 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q8NDG6 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 122402 | ||||||||||||||||||
UniGene | Hs.626253 | ||||||||||||||||||
RefSeq | |||||||||||||||||||
HUGO | HGNC:20122 | ||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | |||||||||||||||||||
HPRD | 15484 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AK093483 AK097429 AK097699 AK125978 AL132712 AL136001 AL833915 BC016796 BC128057 | ||||||||||||||||||
GenPept | AAH16796 AAI28058 BAC04182 BAC05047 BAC05144 BAC86372 CAD38771 | ||||||||||||||||||