Version 5.4
Homo sapiens Protein: OSGEP
Summary
InnateDB Protein IDBP-2239.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSGEP
Protein Name O-sialoglycoprotein endopeptidase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000206542
InnateDB Gene IDBG-2237 (OSGEP)
Protein Structure
UniProt Annotation
Function Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. {ECO:0000255HAMAP-Rule:MF_03180}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03180}. Nucleus {ECO:0000255HAMAP-Rule:MF_03180, ECO:0000269PubMed:22912744}.
Disease Associations
Tissue Specificity Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas. {ECO:0000269PubMed:12039036}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 82 experimentally validated interaction(s) in this database.
Experimentally validated
Total 82 [view]
Protein-Protein 81 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0070526 threonylcarbamoyladenosine biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000905 Gcp-like domain
IPR017861 Kae1/YgjD family
PFAM PF00814
PRINTS PR00789
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPF4
PhosphoSite PhosphoSite-Q9NPF4
TrEMBL G3V4G5
UniProt Splice Variant
Entrez Gene 55644
UniGene Hs.597888
RefSeq NP_060277
HUGO HGNC:18028
OMIM 610107
CCDS CCDS9549
HPRD 10133
IMGT
EMBL AB047823 AB050442 AJ271669 AK000418 AL355075 BC032310 CH471078 CR457232
GenPept AAH32310 BAA91150 BAB33147 BAB33172 CAB71031 CAG33513 EAW66470

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca