Version 5.4
Homo sapiens Protein: GAPT
Summary
InnateDB Protein IDBP-22581.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAPT
Protein Name GRB2-binding adaptor protein, transmembrane
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323075
InnateDB Gene IDBG-22579 (GAPT)
Protein Structure
UniProt Annotation
Function Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:18559951}; Single-pass membrane protein {ECO:0000269PubMed:18559951}.
Disease Associations
Tissue Specificity Highly expressed in spleen and PBL, detected at lower levels in thymus, and undetectable in all other tissues tested. Also expressed in various B-cell lines, monocytic cell line THP-1 and NK-like cell line YT, but not in T-cell line Jurkat or HeLa cells. {ECO:0000269PubMed:18559951}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0042113 B cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR021082 Protein GAPT
PFAM PF11770
PRINTS PR02077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N292
PhosphoSite PhosphoSite-Q8N292
TrEMBL D6RBK7
UniProt Splice Variant
Entrez Gene 202309
UniGene Hs.547697
RefSeq XP_005248524
HUGO HGNC:26588
OMIM
CCDS CCDS3975
HPRD 08161
IMGT
EMBL AC008814 AK090960 BC063534 CH471123
GenPept AAH63534 BAC03557 EAW54974 EAW54975

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca