InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HIP1

Summary

InnateDB Protein

IDBP-22643.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HIP1

Protein Name

huntingtin interacting protein 1

Synonyms

HIP-I; ILWEQ;

Species

Homo sapiens

Ensembl Protein

ENSP00000336747

InnateDB Gene

IDBG-22641 (HIP1)

Protein Structure

UniProt Annotation

Function

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. {ECO:0000269PubMed:11007801, ECO:0000269PubMed:11532990, ECO:0000269PubMed:11577110, ECO:0000269PubMed:11889126, ECO:0000269PubMed:12163454, ECO:0000269PubMed:14732715, ECO:0000269PubMed:16027218, ECO:0000269PubMed:9147654}.

Subcellular Localization

Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.

Disease Associations

Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.

Tissue Specificity

Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer. {ECO:0000269PubMed:12163454, ECO:0000269PubMed:9140394, ECO:0000269PubMed:9147654}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.

Experimentally validated
Total	30 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005488	binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030276	clathrin binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030154	cell differentiation
GO:0042981	regulation of apoptotic process
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048268	clathrin coat assembly
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0030136	clathrin-coated vesicle
GO:0030665	clathrin-coated vesicle membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001026 Epsin domain, N-terminal
IPR002558 I/LWEQ domain
IPR008942 ENTH/VHS
IPR009053 Prefoldin
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal
IPR016024 Armadillo-type fold

PFAM

PF01417
PF01608
PF07651

PRINTS

PIRSF

SMART

SM00307
SM00273

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00291